Green light for Golgi traffic
نویسندگان
چکیده
منابع مشابه
Green light for traffic in the early secretory pathway.
The endomembrane system, which includes the endoplasmic reticulum (ER), the Golgi apparatus, vacuoles, and associated vesicles, functions in the biosynthesis and transport of lipids, proteins, and cell wall polysaccharides destined for various locations within the cell, the maintenance of cell integrity, and the detoxification of foreign molecules that gain entry into the cell. In fact, this pa...
متن کاملModels for Golgi traffic: a critical assessment.
A variety of secretory cargoes move through the Golgi, but the pathways and mechanisms of this traffic are still being debated. Here, we evaluate the strengths and weaknesses of five current models for Golgi traffic: (1) anterograde vesicular transport between stable compartments, (2) cisternal progression/maturation, (3) cisternal progression/maturation with heterotypic tubular transport, (4) ...
متن کاملTraffic through the Golgi apparatus
The role of vesicles in cargo transport through the Golgi apparatus has been controversial. Large forms of cargo such as protein aggregates are thought to progress through the Golgi stack by a process of cisternal maturation, balanced by a return flow of Golgi resident proteins in COPI-coated vesicles. However, whether this is the primary role of vesicles, or whether they also serve to transpor...
متن کاملA cycling cis-Golgi protein mediates endosome-to-Golgi traffic.
Toxins can invade cells by using a direct endosome-to-Golgi endocytic pathway that bypasses late endosomes/prelysosomes. This is also a route used by endogenous proteins, including GPP130, which is an integral membrane protein retrieved via the bypass pathway from endosomes to its steady-state location in the cis-Golgi. An RNA interference-based test revealed that GPP130 was required for effici...
متن کاملGreen light for selected baby
Zain Hashmi is a three-year-old little boy from northern England with big brown eyes and a fatal disease, beta thalassaemia major. As his bone marrow is unable to produce sufficient numbers of red blood cells, he needs regular transfusions and is unlikely to survive for long unless transplanted with suitable stem cells. These could come from the bone marrow of a donor with matching tissue type,...
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ژورنال
عنوان ژورنال: Nature
سال: 1997
ISSN: 0028-0836,1476-4687
DOI: 10.1038/37870